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[DOI] [PubMed] [Google Scholar] 24.Richie J.P., Jr., Nichenametla S., Neidig W., Calcagnotto A., Haley J.S., Schell T.D., Muscat J.E

Changes in opioid receptor expression, especially MOR, reduce the inhibitory function and efficiency of endogenous opioid peptides when the body responds to nociceptive stimuli, enhances neuronal excitability, and promotes the occurrence of sensory sensitization and the development of NP [81,103]

Furthermore, in a paraquat-induced fibrosis model, Xuebijing injection, a traditional Chinese medicine compound, corrected elevated levels of L-valine, glycine, and L-tryptophan, indicating its antifibrotic potential may be related to rebalancing amino acid metabolic disturbances [165]

The histological examination of major organs in the experimental mice revealed no significant morphological abnormalities among the different groups (Fig