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As reported in Figure 2 in response to the hypothalamic gonadotropin hormone releasing (GnRH), the pituitary gland secretes two hormones, the luteinizing hormone (LH), and the follicle stimulating hormone (FSH), involved in the regulation of spermatogenesis, together with other important transcription factors (3)

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Additionally, galiellalactone lowered the expression of the indoleamine 2,3-dioxygenase gene and reduced the secretion of IL-8 and granulocytemacrophage colony-stimulating factor by PC cells [119]