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doi: 10.1016/j.ecl.2017.11.002 7 BartnikMRydnLFerrariRMalmbergKPyrlKSimoonsMet al

COX-2 is an N-glycoprotein with 4 glycosylation sites 33 , and it has been shown that inhibition of COX-2 N-glycosylation by site-directed mutagenesis or pharmacologically using an N-glycosylation inhibitor leads to the production of a COX-2 protein with reduced molecular mass and activity 34

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22 More recently, in osteosarcoma cells, GSTP1 has been shown to interfere not only with JNK pathway but also with tumor necrosis factor receptor-associated factor 2 (TRAF2) signaling resulting in the inhibition of P38 and JNK phosphorylation