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doi: 10.3389/fimmu.2019.02386 157 YePHLiCYChengHYAnuragaGWangCYChenFWet al

GLP-1s are meant to be taken long-term, alongside lifestyle changes including more physical activity and a balanced food intake, and under a healthcare providers supervision

This might lead to disease by reducing the capacity to produce sufficient energy during times of stress such as with fever, illness, hot weather (sweating), excitement and exercise