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The 1998 version (24) views the acinar cell as the site of mounting electrophilic stress that steadily erodes methyl (CH 3 ) and thiol (SH) - principally glutathione (GSH ) - moieties, as a result of CYP induction, concurrent exposure to a toxicant that yields RXS, and insufficiency of refurbishing micronutrients (Figure 1)

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Scalable algorithms for molecular dynamics simulations on commodity clusters