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In fact, MOTS-c levels naturally rise during exercise, and giving MOTS-c to mice has been shown to enhance their physical performance (they can run longer on a treadmill)
89 ShinA
Acknowledgements The authors gratefully acknowledge the support of the National Institute of Dental and Craniofacial Research (NIDCR), and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health, under award numbers UG3/UH3DE027695 to DSWB, CEO, and LAD, NIEHS Environmental Health Sciences Center T32 ES007026 to JAM, and F31 DE029658 to LRP
Nevertheless, increasing proof indicates that metformin primarily acts on the gastrointestinal system
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