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Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

In addition to physical enhancement, transcriptional control through inflammation-responsive promoter systems such as those regulated by NF-KB can ensure greater transgene specificity

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This large-scale, real-world data validates the widespread use of NAC in post-COVID clinics and highlights its accessibility as an over-the-counter option for patients desperate for symptom relief while waiting for formal pharmaceutical approvals