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When there are defects in INSR, including decreased expression of INSR on the surface of cells and decreased activity of receptor tyrosine kinase, decreased INSR levels in obese mice and human fat cells, and decreased IRK activity in diabetic rats ( 4 Mechanism of PYY improving insulin resistance PYY improves insulin resistance not through a single mechanism, but via a complex network of regulatory pathways involving the central nervous system and multiple peripheral metabolic organs