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However, 1/10 the normal NAC rescue (solid blue) and 1/20 the normal NAC rescue (solid green) substantially delay the time of GSH rebound and decrease substantially the curves showing the time course of functional hepatocytes

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Real-world data from the FDA Adverse Event Reporting System shows that 77.44% of gastrointestinal side effects occur within the first 30 days, with a median onset time of just 1 day