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Converts white adipose tissue into brown adipose tissue (a phenomenon called fat tissue browning) to prevent body disfigurement associated with obesity and overweight

The following individual and combined search terms were used: GLP-1, Semaglutide and Liraglutide, molecular mechanism, lipid metabolism, insulin metabolism, glucose homeostasis, energy expenditure obesity treatment, type 2 diabetes mellitus, side effects, clinical trials, treatment option, fatty liver disease, hypertension, neurodegenerative diseases, cardiovascular diseases, therapeutic options. Only articles published in the last 10 years are included, although older pivotal studies were added

doi: 10.1016/j.cmet.2019.05.008

The agency is not aware of any basis for compounding using the salt forms that would meet the FD&C requirements for types of active ingredients that can be compounded