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This is especially true with long-term or repeated use of pain medications, where short-term relief can mask progressive systemic side effects

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It is associated with a wide range of clinical complications, such as cardiovascular diseases (e.g., ischemic heart disease and heart failure), metabolic disorders like type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, obstructive sleep apnoea syndrome, knee osteoarthritis, mental health disorders, and certain types of cancer [2, 3]

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