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Although the mainstream of HnB systems contains several classes of harmful chemicals typically recorded in traditional tobacco smoke, such as toxic aldehydes and carcinogenic polycyclic aromatic hydrocarbons (PAHs), concentrations were found to be significantly lower (Vivarelli et al., 2022

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Opioid and alcohol withdrawal Clonidine and other alpha-2 agonists lessen symptoms of autonomic hyperactivity associated with opioid and alcohol withdrawal, including sweating, diarrhea, intestinal cramps, nausea, anxiety, and irritability (Gold et al, 1978