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6.6 Effects on renal functions The result of clinical trials of tirzepatide on kidney function indicates potential renal advantages, especially in individuals with type-2 diabetes (T2D) and a heightened cardiovascular risk.In the SURPASS-4 (NCT03730662) trial, tirzepatide was observed to reduce occurrence of the composite kidney endpoint (like eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new-onset macro albuminuria) in comparison to those receiving insulin glargine
The good news is that these usually occur during the "dose escalation" phase and subside as the body adapts
Spinal localization was as follows: 4 cervical (16.67%), 7 thoracic (29.17%), 9 lumbar (37.5%), and 4 sacral (16.67%)
If you have a history of pancreatitis or heavy alcohol use, it is critical that you discuss this with your provider before starting treatment, as this medication may not be right for you
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