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Furthermore, mouse xenograft experiments showed increased IGF-1R prosphorylation in CD45 /CD24 /CD44 + breast cancer stem cell (BCSC), while activation of the PI3K/AKT/mTOR pathway facilitated BCSC maintenance and increased their EMT phenotype indicating a regulatory role for the IGF-1R pathway in BrCa stem/progenitor cells [93]

Research published in World Journal of Gastroenterology (2017) showed that BPC-157 accelerated the healing of gastric ulcers and improved gut barrier function, reducing systemic inflammation in the process (Sikiric et al., 2017)

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