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Instead, we want it to be intact to maintain the structural integrity of the connective tissues

This is the sharpest single difference in the comparison, and it colors every downstream statement about dosing and safety

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LA (100 or 200 mg/kg) can act by preventing the activation of the SIRT1/liver kinase B1 (LKB1) AMPK pathway and the translocation of SREBP1 into the nucleus and FOXO1) into the cytoplasm