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You may need to have one or more tests to look for the cause: Angiography Bleeding scan (nuclear medicine) Blood studies, including a complete blood count (CBC) and differential, serum chemistries, clotting studies Colonoscopy Esophagogastroduodenoscopy or EGD Stool culture Tests for the presence of Helicobacter pylori infection Capsule endoscopy (a pill with a built in camera that takes a video of the small intestine) Double balloon enteroscopy (a scope that can reach the parts of the small intestine that are not able to be reached with EGD or colonoscopy) Severe cases of bleeding that cause excessive blood loss and a drop in blood pressure may require surgery or hospitalization