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Its imbalanced receptor affinity and biased signaling provide enhanced insulin secretion and improved metabolic outcomes beyond selective GLP-1 agonism

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Among the immediate-early response genes, expression of c-Jun and c-Fos is induced to form the transcription factor AP-1 that regulates transcription of genes implicated in cell proliferation or differentiation

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The strongest evidence showing H2O2 itself activates transcription factor is provided by the study on yeast transcription factor YAP1 (Coleman et al., 1999)

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