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The human genome contains five GST alpha genes, five mu genes, two omega genes, one pi gene, one sigma gene, two theta genes, and one zeta gene

52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA

Immunogenicity The ability of a foreign substance, such as a viral or non-viral vector, to provoke an undesirable immune response, which can lead to reduced efficacy of the drug, allergic reactions or other adverse reactions