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Further mechanism experiments revealed that dapagliflozin mitigated pro-inflammatory cytokines, nitro-oxidative stress, and fibrosis, as well as reduced apoptosis, and restored autophagy via activating adenosine monophosphate kinase (AMPK) and mTOR pathway [63]

Synbiotic of Pediococcus acidilactici and inulin ameliorates dextran sulfate sodium-induced acute ulcerative colitis in mice

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In addition, glutamine deprivation promotes the differentiation of Treg cells through AMPK-mTORC1 signaling pathway, thereby reducing the immune function of Teff cells (90)