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The intent with propensity-score matching was to identify control patients that were just as likely to have been prescribed GLP-1s as the treatment cohort based on a wide range of observed covariates, and it is reasonable to assume that such patients would be pursuing additional therapies over the study duration that would improve their weight and HbA1c as well

To me, it comes back to seeing health holistically

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Wegovy and Zepbound excluded individuals with depression, psychiatric conditions, or prior reports of suicidal thoughts whereas Ozempic did not survey whether those studied had mental health conditions at all