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MiR-495 was found in the cocaine model to directly target the 30 UTR of multiple genes known to be increased in substance use disorder, such as BDNF and calmodulin-dependent protein kinase II alpha 115

However, after adjusting for key clinical confounders, the association between PAGln and GRACE score was no longer statistically significant, suggesting that the observed correlation may be substantially influenced or confounded by age and renal function

Together, these results indicate that GSH supports lipid abundance by preventing NRF2 activation in the liver