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By adjusting the proportions of different SCFAs in the mouse diet, the characteristics of the gut microbiota are altered, and the expression of G protein-coupled receptors 43/41 (GPCR43/41) in intestinal cells changes (Samuel et al., 2008

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Next, we detail several mechanistic links by which the microbiome can trigger or protect against neurodegeneration spanning immune modulation, metabolic and neuroendocrine signaling, microbial neurotransmitter production, and effects on protein aggregation and epigenetic regulation