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There are a few common, mild side effects associated with B12 shots, including: Mild diarrhea, itching, nausea and vomiting, dizziness, headaches, and hot flashes Redness or swelling at the injection site Temporary soreness at injection site Serious side effects are rare but require immediate medical attention

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Following a vegan or vegetarian diet, having gastrointestinal issues, having pernicious anemia, and taking specific drugs are issues that frequently result in a deficiency