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Senescent stimuli endow cells with resistance to apoptosis, which involves high activity of anti-apoptotic molecules, such as BCL2 and BCL-XL, and reduced pro-apoptotic BAX protein
BAT combusts lipids through the activation of mitochondrial localized uncoupling protein 1 (UCP1) to transport protons and limit adenosine triphosphate (ATP) production, thus generating heat to contribute to thermogenesis and energy expenditure
Collagen and elastin, the proteins responsible for skin tone and firmness, require synthesis stimulation that the body may not provide at an adequate rate on its own, particularly when caloric intake is suppressed
The authors proposed that GHK may be used for prevention of some age-related pathologies, including Alzheimer's disease [40]
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