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In line with these findings, overall lower DNA methylation was reported in NS healthcare workers compared to DS workers in an American cohort, upon adjustments for confounders such as immune cell composition 214

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6 Risk factors (hypertension, diabetes mellitus, smoking, and elevated lipids) cause both oxidative stress and minimal lesions at the high-pressure bifurcations of conducting vessels, which lead to an inflammatory response and the release of chemokines by endothelial cells

Supplementation with glutathione has been met with little success as the bioavailability of glutathione is low due its transient transport throughout the cellular network