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Despite these advantages, many current HILIC methods still rely on chemical derivatization to achieve adequate sensitivity [48, 59,60,61] or depend entirely on MS/MS specificity while neglecting optimal chromatographic separation, which can lead to severe matrix interferences and ion suppression [41]

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The disadvantages of a twostage surgical repair include an additional procedure and scarring, possibly making dissection more difficult during the second, definitive surgery

Postprandially, it has the ability to suppress gastrointestinal motility, delay gastric emptying, reduce appetite, and is also involved in regulating glucose homeostasis