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This signature suggests increased activation of protein damage repair mechanisms catalyzed by enzymes like PCMT1, which responds to oxidant stress-induced dehydration and deamidation of aspartate and asparagine residues, respectively 49

However, for patients with sensitive gastrointestinal tracts or hyper-reactive immune systems, standard vitamin C supplements can sometimes cause more harm than good, triggering acid reflux, stomach cramps, or diarrhea

The study led by Dr Vishnu Shankar, and including well-known researcher Professor Ron Davis within the team, explored bioenergetics (how cells produce and manage energy) in people with ME/CFS and long COVID, focusing on oxidative stress

This study also observed a decrease in circulating plasma GSH and 25(OH)VD 3 in HFD-fed mice