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Therefore, the reduced capacity to carry out the methionine synthase reaction, due to nutritional or disease mediated deficiency of vitamin B12, results in reduced SAM production and as a consequence contributes to the neural degeneration (i.e
MTHFR and the Methylation Cycle Normal role: MTHFR converts 5,10-methylene-tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), the active folate required for homocysteine methionine conversion
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