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SGLT2i use is associated with an increased risk of DKA and UTI, but confers several favourable outcomes, notably preservation of renal function, reduced risk of developing heart failure and CKD, and of hospitalisation, despite a higher prevalence of heart failure, hypertension, IHD and CKD at baseline

Participants receiving the highest doses of retatrutide achieved substantial reductions in body weight compared with those receiving placebo

Regulatory uncertainty persists, as the FDA has yet to finalize its guidance on GLP-1 biosimilars, creating a timing risk for follow-on entrants

This timeframe balances practical portabilityallowing patients to travel or keep medications at their workplacewith safety margins that ensure the compound remains chemically stable