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His 61 , His 85 , His 259 , Asn 260 , His 263 , Phe 264 , Met 280 , Gly 281 , Phe 292 , Ser 282 , Val 283 , and Ala 286 , and copper ion (Cu 401 ) interacting with the co-crystallized tropolone inhibitor in the crystal structure of mh-Tyr 37 were considered for the screening of selected flavonoids (C3G, EC, and CH) and positive control (ARB inhibitor) using extra precision (XP) docking protocol of GLIDE v8.9 tool under default parameters in the Schrdinger suite-2020.4 46

doi: 10.7759/cureus.46741 348 DuHCaiYShenLZhengYZhaoLHuRet al

doi: 10.3389/fpls.2016.01406

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