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The plot provided a visual representation of the relative differences observed between the modified method and the reference protocol, along with the mean relative bias (Barr et al

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For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145