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Polarization was also assessed at the ultrastructural level, revealing features of primary liver tissue, including epithelial cells lining luminal structures arranged in a layer and connected by tight junctions, a feature of the hematobiliary barrier (Fig

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Injection site reactions remain mild and transient in most cases

Access to patient-specific liver organoids harboring coagulation factor deficiencies would allow access to autologous liver cells that can be exploited to elucidate complex genetic defects that cannot currently be detected using patient plasma