Some researchers substitute MK-677 for the Ipamorelin component, producing a hybrid where MK-677 provides the sustained GHSR signal and injectable CJC-1295 provides the GHRH amplification
But when gastric emptying slows too much, especially during the early dose escalation phase, the stomach essentially holds food longer than the body expects
Bondue T, Berlingerio SP, Siegerist F, Sendino-Garvi E, Schindler M, Baelde HJ, Cairoli S, Goffredo BM, Arcolino FO, Dieker J, Janssen MJ, Endlich N, Brock R, Gijsbers R, van den Heuvel L, Levtchenko E (2023) Evaluation of the efficacy of cystinosin supplementation through CTNS mRNA delivery in experimental models for cystinosis
[PubMed] Davies MJ, DAlessio DA, Fradkin J, et al