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After 72 weeks, patients on the highest dose (36 mg) achieved an average weight reduction of 12.4% (about 27 lbs) compared to 0.9% on placebo

A similar reduction of the dynamic range due to amino acid insertion next to Cys147 has already been reported for several roGFP1-iX variants but not for the roGFP1-iL version (Lohman and Remington, in vivo measurements

Contact your GP for B12 testing if you have: Symptoms suggesting deficiency (persistent fatigue, pins and needles, memory problems, glossitis) Risk factors for deficiency (vegan diet, gastric surgery, long-term metformin or proton pump inhibitor use) [1] [4] Concerns about whether your current supplementation dose is appropriate Underlying conditions affecting B12 metabolism (kidney disease, liver disease) Unexplained high B12 levels on a blood test when not taking supplements Routine monitoring is essential for patients receiving therapeutic B12 injections

Vukojevic J, Milavi M, Perovi D, Ili S, ili AZ, uran N, trbe S, Zorii Z, Filipi I, Brei P, Seiverth S, Sikiri P