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10.1016/j.freeradbiomed.2021.12.001 20 ChenW

Systemic immune activation leads to neuroinflammation and sickness behavior in mice

For instance, in the presence of the antibiotic metronidazole, thiaminase I substitutes the thiazolium ring of thiamine with the imidazolium ring of metronidazole, resulting in a thiamine antagonist which can inhibit TPK (160)

B12 helps convert carbohydrates into glucosethe bodys primary energy sourceso addressing a deficiency can quickly restore vitality and reduce feelings of tiredness or weakness