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48, 49 However, claudin-2 also serves other diverse functions including paracellular passage of cations (including sodium and calcium), cell proliferation and autophagy, and loss of claudin-2 along with claudin-15, yet another TJ protein implicated in paracellular Na + passage, results in premature death because of malnourishment in mice

For patients primarily focused on peptides for muscle gain with fat loss as a secondary outcome, CJC-1295/Ipamorelin or Tesamorelin alone is typically sufficient, with the understanding that the elevated IGF-1 environment naturally supports more favorable nutrient partitioning

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