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4.2.4 Self-emulsifying drug delivery systems Self-emulsifying drug delivery systems (SEDDSs) represent lipid-based formulations that spontaneously form emulsions or microemulsions in gastrointestinal environments, including self-nanoemulsifying DDSs and self-microemulsifying DDSs (SMEDDSs), significantly enhancing the oral bioavailability of lipophilic drugs ( ex vivo degradation (Haddadzadegan et al., 2022

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