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A volume of 350 L of 0.1 M potassium phosphate buffer (pH 7.4), 50 L of 1 mM substrate (diclofenac for CYP2C9 assay and dextromethorphan for CYP2D6, both substrates purchased from Sigma-Aldrich, USA) and 50 L of 2.5 mg/mL microsome (obtained from rat livers from respective groups) were mixed separately in Eppendorf tubes

To evaluate the functional relevance of the GLP-1R cholesterol binding sites identified during the cgMD simulations, 12 residues were selected within or at the periphery of these sites and mutated to alanine by site-directed mutagenesis (Figure 2F)

Catts SV, Shelley AM, Ward PB, Liebert B, McConaghy N, Andrews S et al (1995)

Many laboratories studying growth hormone signaling also examine related peptides such as CJC-1295 , which interacts with similar biological pathways