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Clonidine is a medication commonly prescribed to treat high blood pressure, attention deficit hyperactivity disorder (ADHD), and certain pain conditions

This is impractical for maintenance dosing but the right choice for research protocols that demand fine-grained dose control

[3] : 313 The most common cause in developed countries is impaired absorption due to loss of gastric intrinsic factor (IF), required for absorption

The requirement of a protein pre- or post-organ and -animal development is an important distinction that is not always considered in studies involving tissue-specific knockout mouse models but potentially requires additional investigation