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Basket trials extend this logic across histologies, as demonstrated by durable responses to TRK inhibitors in NTRK fusionpositive cancers and by recent KRAS-G12C inhibitor trials that reveal tissue-specific adaptive resistance mechanisms (212, 213)

Add 20 L of the diluted GPX positive control, Assay Buffer (served as a blank), or sample to each well of a 96-well microtiter plate