[1] In experimental models, the peptide appears to influence several pathways involved in healing: angiogenesis, fibroblast migration, collagen organization, nitric oxide signaling, extracellular matrix formation, and reducing inflammatory cytokines
While these fluctuations are generally mild, they can be concerning for individuals with pre-existing cardiovascular conditions
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In adults over 55, prolonged-release melatonin improved sleep quality and morning alertness in a randomized trial of 354 people [6]