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Damage to the lining of the stomach and small intestine results in symptoms that range from relatively minor heartburn, nausea, and abdominal pain (affecting 15-40% of NSAID users) to the life-threatening ulceration, perforation, and bleeding (affecting 1-2% of chronic NSAID users) (Vonkeman 2010)

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At the cellular level, after AOD 9604 acts on adipocytes, a decrease in triglyceride content within adipocytes and an increase in the release of free fatty acids can be observed