Eryptosis and aging Multicellular organisms are subject to the biological process of aging, and recently 12 different hallmarks of aging have been defined: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, dysregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis [415]
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Harris Distinguished Professor of Pediatrics Professor of Pediatrics Professor of Pathology Member of the Duke Cancer Institute Affiliate of the Duke Regeneration Center Professor of Pathology Member of the Duke Cancer Institute Affiliate of the Duke Regeneration Center
Plattner H, Verkhratsky A