however, direct clinical evidence regarding their role in the prevention and treatment of high-altitude sickness is lacking
Heres why: For people with PCOS and obesity or overweight, shedding 5%--15% of body weight within six months is commonly recommended to improve irregular periods, insulin resistance, infertility, and other issues related to high androgen levels
So at least in that regard, if patients are obtaining drug from a pharmacy that has a reputation for quality products, I feel a little more comfortable, but as you mentioned, the regulation is not as robust, if you will.
The distance could even be further reduced to 2.2 through a slight movement and rotation of Cys168, which would permit the formation of an intra-molecular disulfide bond