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Only one study has investigated ADHD in patients with systemic lupus erythematosus, and found NAC, at dosages of 2400 and 4800 mg per day for 3 months, to be effective in reducing ADHD scores, with a trend to the higher dose being more effective

Topical delivery bypasses this, potentially providing more consistent plasma concentrations at lower absolute doses

Nonetheless, because autism is influenced by multiple interacting genetic and environmental factors that are case-specific and inherent limitations in post-mortem brain, these observations will require confirmation in subsequent studies

Fabbrini E, Serafini M, Colic Baric I, Hazen SL, Klein S