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Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

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The Evidence: Randomized placebo-controlled studies demonstrate that Transcranial PBM significantly reduces the number of headache days per month by raising the brain's metabolic threshold and reducing cortical hyperexcitability [5]

Over the past several years, researchers have examined large patient populations using real-world evidence, clinical trial follow-ups, and pharmacovigilance databases