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Additionally, we examined mitochondrial morphology in neurons and found that PPARa over-expression improved mitochondrial structure and cristae density, further supporting its protective role against ferroptosis (Fig

In cells exposed to high levels of oxidative stress, like red blood cells (RBC), up to 10% of the glucose consumption may be directed to the pentose phosphate pathway (PPP) for the production of the NADPH needed for this reaction

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