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A clinically defensible pathway therefore requires standardizing pre-analytics (cycle type, progesterone route, biopsy timing/site), clarifying the clinical question (timing correction vs endotype diagnosis), and integrating receptivity readouts with complementary layers when disruption is suspected, such as immune profiling and endometrial/uterine fluid proteomics/metabolomics, so that non-receptive is interpreted within a multi-dimensional endometrial endotype framework rather than as a single timing label

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doi: 10.1038/nrn.2017.168 56 HanJBackSHHurJLinYHGildersleeveRShanJet al

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