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Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimers disease

For example, the combination of 2-deoxyglucose (glycolytic inhibitor), metformin (glycolytic inhibitor), compound C (an AMPK inhibitor), MLN128 (mTOR1 inhibitor), and other glutamine metabolism inhibitors have shown synergistic antitumor effects in some cancer models (Elgogary et al., 2016