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Potential for Improved Tolerability: The avoidance of -arrestin recruitment may also help improve the tolerability of the drug, since a common side effect associated with GLP-1 receptor agonists is gastrointestinal distress

Label updates in 20242025 expanded Warnings and Precautions for acute kidney injury due to volume depletion, severe GI adverse reactions, and periprocedural aspiration risk, reflecting evolving safety understanding

Half-life & frequency rationale Cagrilintide has a long plasma half-life reported at roughly 7-8 days (approximately 159-195 hours across studied doses), which is the basis for once-weekly dosing in trials